Pyr3

Name: Pyr3
Brand: Tocris Bioscience
SKU: 3751
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3751

(1)

Citations (47)

COA / SDS

Selective TRPC3 inhibitor

Key Product Details

Description:	Selective TRPC3 inhibitor
Chemical Name:	1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	456.63

View Full Technical Details for Pyr3

Technical Data
Citations / Reviews (1)

Biological Activity for Pyr3

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca²⁺ influx (IC₅₀ = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

Technical Data for Pyr3

M. Wt	456.63
Formula	C₁₆H₁₁Cl₃F₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1160514-60-2
PubChem ID	56964346
InChi Key	RZHGONNSASQOAY-UHFFFAOYSA-N
Smiles	O=C(/C(Cl)=C(Cl)\Cl)NC(C=C2)=CC=C2N1N=CC(C(OCC)=O)=C1C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pyr3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.66	100

Preparing Stock Solutions for Pyr3

The following data is based on the product molecular weight 456.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.95 mL	21.90 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for Pyr3

References are publications that support the biological activity of the product.

Kiyonaka Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc.Natl.Acad.Sci.