Pyr 10

Name: Pyr 10
Brand: Tocris Bioscience
SKU: 6941
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6941

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Citations (1)

COA / SDS

Selective TRPC3 inhibitor

Key Product Details

Description:	Selective TRPC3 inhibitor
Chemical Name:	N-[4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	449.37

View Full Technical Details for Pyr 10

Technical Data
Citations / Reviews (1)

Biological Activity for Pyr 10

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC₅₀ = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.

Technical Data for Pyr 10

M. Wt	449.37
Formula	C₁₈H₁₃F₆N₃O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1315323-00-2
PubChem ID	53475435
InChi Key	CVALMMCIOLXHDM-UHFFFAOYSA-N
Smiles	CC1=CC=C(S(=O)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pyr 10

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	44.94	100

Preparing Stock Solutions for Pyr 10

The following data is based on the product molecular weight 449.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.13 mL	22.25 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for Pyr 10

References are publications that support the biological activity of the product.

Saliba Transient receptor potential canonical 3 and nuclear factor of activated T cells C3 signaling pathway critically regulates myocardial fibrosis. Antioxid.Redox.Signal. 2019 PMID: 30318928
Schleifer Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca²⁺ entry pathways. Br.J.Pharmacol. 2012 PMID: 22862290