Puromycin dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4089

Protein synthesis inhibitor
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Key Product Details

Description

Protein synthesis inhibitor

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Product Description

Puromycin dihydrochloride is a protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.

Product Specifications

Molecular Weight

544.43

Formula

C22H29N7O5.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

CAS Number

58-58-2

PubChem ID

443311

InChI Key

MKSVFGKWZLUTTO-FZFAUISWSA-N

SMILES

O[C@@H]1[C@H](NC([C@@H](N)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 54.44 100
DMSO 54.44 100

Preparing Stock Solutions for Puromycin dihydrochloride

The following data is based on the product molecular weight 544.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.18 mL 18.37 mL
5 mM 0.37 mL 1.84 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Puromycin dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Puromycin dihydrochloride

For research use only

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