Psora 4

Name: Psora 4
Brand: Tocris Bioscience
SKU: 4367
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4367

(1)

Citations (8)

COA / SDS

Potent KV1.3 channel blocker

Key Product Details

Description:	Potent K_V1.3 channel blocker
Chemical Name:	4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
Purity:	≥98% (HPLC)
Molecular Weight:	334.37

View Full Technical Details for Psora 4

Technical Data
Citations / Reviews (1)

Biological Activity for Psora 4

Psora 4 is a potent K_V1.3 channel blocker (EC₅₀ = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related K_V1 channels (K_V1, K_V2, K_V4 and K_V7); exhibits activity at K_V1.5 (IC₅₀ = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC₅₀ values are 25 and 60 nM respectively).

Technical Data for Psora 4

M. Wt	334.37
Formula	C₂₁H₁₈O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	724709-68-6
PubChem ID	6603977
InChi Key	JJAWGNIQEOFURP-UHFFFAOYSA-N
Smiles	O=C2OC1=CC3=C(C=CO3)C(OCCCCC4=CC=CC=C4)=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Psora 4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.72	50
	ethanol	3.34	10

Preparing Stock Solutions for Psora 4

The following data is based on the product molecular weight 334.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.98 mL	29.91 mL	59.81 mL
2.5 mM	1.20 mL	5.98 mL	11.96 mL
5 mM	0.60 mL	2.99 mL	5.98 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

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References for Psora 4

References are publications that support the biological activity of the product.

Schmitz Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol.Pharmacol. 2005 PMID: 16099841
Li Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca²⁺-dependent mechanism. Am.J.Physiol.Cell Physiol. 2006 PMID: 16403947
Vennekamp Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol.Pharmacol. 2004 PMID: 15155830