Psora 4

Product Description

Psora 4 is a potent K_V1.3 channel blocker (EC₅₀ = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related K_V1 channels (K_V1, K_V2, K_V4 and K_V7); exhibits activity at K_V1.5 (IC₅₀ = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC₅₀ values are 25 and 60 nM respectively).

Solubility

Preparing Stock Solutions for Psora 4

The following data is based on the product molecular weight 334.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.98 mL	29.91 mL	59.81 mL
2.5 mM	1.20 mL	5.98 mL	11.96 mL
5 mM	0.60 mL	2.99 mL	5.98 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schmitz Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol.Pharmacol. 2005 PMID: 16099841
• Li Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca²⁺-dependent mechanism. Am.J.Physiol.Cell Physiol. 2006 PMID: 16403947
• Vennekamp Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol.Pharmacol. 2004 PMID: 15155830