PSEM 89S
Tocris Bioscience, part of Bio-Techne | Catalog # 6426
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Key Product Details
Description
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Product Description
PSEM 89S is a PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
Product Specifications
Molecular Weight
404.38
Formula
C16H22N2O3.CF3CO2H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
CAS Number
1336913-03-1
PubChem ID
134812840
InChI Key
GLKCNNXBIUCCJJ-PFEQFJNWSA-N
SMILES
OC(C(F)(F)F)=O.O=C(N[C@@H]1CN2CCC1CC2)C(C=C3OC)=C(C=C3)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 40.44 | 100 | |
| DMSO | 40.44 | 100 |
Preparing Stock Solutions
for PSEM 89S
The following data is based on the product molecular weight 404.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cerritelli Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 2016 PMID: 27077912
- Magnus Chemical and genetic engineering of selective ion channel-ligand interactions. Science 2011 PMID: 21885782
Product Specific Notices for PSEM 89S
For research use only
Loading...
Loading...