Protamine sulfate

Tocris Bioscience, part of Bio-Techne | Catalog # 8822

Transduction efficiency enhancer, also apelin receptor antagonist
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Key Product Details

Description

Transduction efficiency enhancer, also apelin receptor antagonist

View all Viral Transduction Enhancers »

Product Description

Protamine sulfate is a cationic peptide that enhances viral vector transduction efficiency in gene therapy applications. By neutralizing charge repulsion between viral particles and the cell surface, Protamine sulfate promotes vector attachment and uptake, leading to increased transduction efficiency. It is commonly used in combination with Polybrene (Cat. No. 7711) to enhance the delivery of adeno-associated virus (AAV) and lentiviral vectors. Protamine sulfate is widely applied in gene delivery workflows, including stem cell engineering and gene-modified cell therapy development. It is also an antagonist of apelin receptor.

For more information on how to prepare Protamine sulfate for transfection enhancement, please see our protocol.

For more information on how to prepare Protamine sulfate for enhanced-viral-transduction of mammalian cells, please see our protocol.

Protamine sulfate is supplied as a lyophilized solid in a convenient, ready-to-reconstitute vial size. A stock solution can be prepared by adding 1 mL of sterile ultra-pure water directly to the vial (final stock concentration: 5 mg/mL).

Product Specifications

Storage

Store at +4°C

Purity

≥90% (HPLC)

CAS Number

53597-25-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 5mg/ml in water with gentle warming

Calculators

Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Protamine sulfate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Protamine sulfate

For research use only

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