ProK

Name: ProK
Brand: Tocris Bioscience
SKU: 7361

Tocris Bioscience, part of Bio-Techne | Catalog # 7361

COA / SDS

Unnatural amino acid, propargyl lysine derivative

Key Product Details

Description:	Unnatural amino acid, propargyl lysine derivative
Chemical Name:	N⁶-[(2-Propyn-1-yloxy)carbonyl]-L-lysine hydrochloride
Purity:	≥95%
Molecular Weight:	264.71

View Full Technical Details for ProK

Technical Data
Citations

Biological Activity for ProK

ProK is a lysine-based unnatural amino acid (UAA) used for genetic code expansion. It enables bioconjugation of fluorescent probes in E. coli or multicellular organisms.

Technical Data for ProK

M. Wt	264.71
Formula	C₁₀H₁₆N₂O₄.HCl
Storage	Store at -20°C
Purity	≥95%
CAS Number	1428330-91-9
PubChem ID	118898827
InChi Key	ZYUXGVUWYHHZTD-QRPNPIFTSA-N
Smiles	C(NCCCC[C@@H](C(O)=O)N)(OCC#C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ProK

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.47	100
	water	26.47	100

Preparing Stock Solutions for ProK

The following data is based on the product molecular weight 264.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.78 mL	18.89 mL	37.78 mL
5 mM	0.76 mL	3.78 mL	7.56 mL
10 mM	0.38 mL	1.89 mL	3.78 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Molarity Calculator

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Reconstitution Calculator

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References for ProK

References are publications that support the biological activity of the product.

Meineke Site-specific incorporation of two ncAAs for two-color bioorthogonal labeling and crosslinking of proteins on live mammalian cells. Cell Rep. 2020 PMID: 32579937
Greiss Expanding the genetic code of an animal. J.Am.Chem.Soc. 2011 PMID: 21819153
Neumann Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature 2010 PMID: 20154731
Li Palladium-triggered deprotection chemistry for protein activation in living cells. Nat. Chem. 2014 PMID: 24651204
Nguyen Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. J.Am.Chem.Soc. 2009 PMID: 19514718