Proglumide sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 1478
Non-selective CCK antagonist; orally active
Key Product Details
Description
Non-selective CCK antagonist; orally active
Product Description
Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.Product Specifications
Molecular Weight
356.39
Formula
C18H25N2NaO4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
CAS Number
99247-33-3
PubChem ID
23677833
InChI Key
UFMWGCINVOIJSO-UHFFFAOYSA-M
SMILES
[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.64 | 100 |
Preparing Stock Solutions
for Proglumide sodium salt
The following data is based on the product molecular weight 356.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.06 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mauss Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 1994 PMID: 8166452
- Hahne Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 1981 PMID: 6171817
- Iwamoto In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 1984 PMID: 6202584
Product Specific Notices for Proglumide sodium salt
For research use only
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