Prochlorperazine dimaleate

Name: Prochlorperazine dimaleate
Brand: Tocris Bioscience
SKU: 3287

Tocris Bioscience, part of Bio-Techne | Catalog # 3287

Citations (2)

COA / SDS

D2 receptor antagonist; also 5-HT3 and nAChR antagonist

Discontinued Product

3287 has been discontinued. View all Dopamine D2 Receptor Antagonists products.

Key Product Details

Description:	D₂ receptor antagonist; also 5-HT₃ and nAChR antagonist
Chemical Name:	2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate
Purity:	≥98% (HPLC)
Molecular Weight:	606.09

View Full Technical Details for Prochlorperazine dimaleate

Technical Data
Citations

Biological Activity for Prochlorperazine dimaleate

D₂ receptor antagonist. Also interacts with 5-HT₃ and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

Compound Libraries for Prochlorperazine dimaleate

Prochlorperazine dimaleate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Prochlorperazine dimaleate

M. Wt	606.09
Formula	C₂₀H₂₄ClN₃S.2C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	84-02-6
PubChem ID	5281032
InChi Key	DSKIOWHQLUWFLG-SPIKMXEPSA-N
Smiles	O=C(O)/C=C\C(O)=O.ClC4=CC2=C(C=C4)SC1=CC=CC=C1N2CCCN3CCN(C)CC3.O=C(O)/C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Prochlorperazine dimaleate

References are publications that support the biological activity of the product.

Ghelardini Prochlorperazine induces central antinociception mediated by the muscarinic system. Pharmacol.Res. 2004 PMID: 15225680
Satoh The antipsychotic and antiemetic drug prochlorper. delays the ventricular repolarization of the in situ canine heart. J.Pharm.Sci.
Lummis and Baker Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT₃ receptors. Neuropharmacology 1997 PMID: 9225292