Pritelivir
Tocris Bioscience, part of Bio-Techne | Catalog # 7321
Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
Key Product Details
Description
Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
Product Description
Pritelivir is a potent and selective herpes simplex virus (HSV) helicase primase inhibitor. Pritelivir inhibits viral replication in Vero cells (IC50 = 0.02 μM for HSV-1 and HSV-2). It also reduces β-amyloid and P-tau levels in Vero cells. Pritelivir is active against clinical isolates and porcine and bovine HSV strains but displays reduced activity against varicella zoster virus and cytomegalovirus in vitro. In addition, the compound exhibits antiviral activity in HSV infected mice.Product Specifications
Molecular Weight
402.49
Formula
C18H18N4O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-(Aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)benzeneacetamide
CAS Number
348086-71-5
PubChem ID
491941
InChI Key
IVZKZONQVYTCKC-UHFFFAOYSA-N
SMILES
O=C(N(C1=NC(=C(S1)S(=O)(=O)N)C)C)CC=2C=CC(=CC2)C3=NC=CC=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.12 | 50 with gentle warming |
Preparing Stock Solutions
for Pritelivir
The following data is based on the product molecular weight 402.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.97 mL | 24.85 mL | 49.69 mL |
| 2.5 mM | 0.99 mL | 4.97 mL | 9.94 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.97 mL |
| 25 mM | 0.10 mL | 0.50 mL | 0.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wozniak The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1. Antiviral Res. 2013 PMID: 23867133
- Kleymann New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat.Med. 2002 PMID: 11927946
Product Specific Notices for Pritelivir
For research use only
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