Pritelivir

Name: Pritelivir
Brand: Tocris Bioscience
SKU: 7321

Tocris Bioscience, part of Bio-Techne | Catalog # 7321

Citations (2)

COA / SDS

Potent and selective herpes simplex virus (HSV) helicase primase inhibitor

Key Product Details

Description:	Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
Chemical Name:	N-[5-(Aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)benzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	402.49

View Full Technical Details for Pritelivir

Technical Data
Citations

Biological Activity for Pritelivir

Pritelivir is a potent and selective herpes simplex virus (HSV) helicase primase inhibitor. Pritelivir inhibits viral replication in Vero cells (IC₅₀ = 0.02 μM for HSV-1 and HSV-2). It also reduces β-amyloid and P-tau levels in Vero cells. Pritelivir is active against clinical isolates and porcine and bovine HSV strains but displays reduced activity against varicella zoster virus and cytomegalovirus in vitro. In addition, the compound exhibits antiviral activity in HSV infected mice.

Technical Data for Pritelivir

M. Wt	402.49
Formula	C₁₈H₁₈N₄O₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	348086-71-5
PubChem ID	491941
InChi Key	IVZKZONQVYTCKC-UHFFFAOYSA-N
Smiles	O=C(N(C1=NC(=C(S1)S(=O)(=O)N)C)C)CC=2C=CC(=CC2)C3=NC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pritelivir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.12	50 with gentle warming

Preparing Stock Solutions for Pritelivir

The following data is based on the product molecular weight 402.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.97 mL	24.85 mL	49.69 mL
2.5 mM	0.99 mL	4.97 mL	9.94 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
25 mM	0.10 mL	0.50 mL	0.99 mL

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Reconstitution Calculator

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References for Pritelivir

References are publications that support the biological activity of the product.

Wozniak The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1. Antiviral Res. 2013 PMID: 23867133
Kleymann New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat.Med. 2002 PMID: 11927946