Pregnanolone
Tocris Bioscience, part of Bio-Techne | Catalog # 3652
Postitive allosteric modulator of GABAA receptors
Key Product Details
Description
Postitive allosteric modulator of GABAA receptors
Product Description
Pregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.Product Specifications
Molecular Weight
318.49
Formula
C21H34O2
Storage
Store at RT
Chemical Name
(3α,5β)-3-Hydroxy-pregnan-20-one
CAS Number
128-20-1
PubChem ID
31402
InChI Key
AURFZBICLPNKBZ-YZRLXODZSA-N
SMILES
C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 100 | |
| Ethanol | 31.85 | 100 |
Preparing Stock Solutions
for Pregnanolone
The following data is based on the product molecular weight 318.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.70 mL | 31.40 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Morris Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 1999 PMID: 10496958
- Harrison Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 1987 PMID: 3033209
Product Specific Notices for Pregnanolone
For research use only
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