Pregnanolone

Name: Pregnanolone
Brand: Tocris Bioscience
SKU: 3652

Tocris Bioscience, part of Bio-Techne | Catalog # 3652

Citations (7)

COA / SDS

Postitive allosteric modulator of GABAA receptors

Key Product Details

Description:	Postitive allosteric modulator of GABA_A receptors
Chemical Name:	(3α,5β)-3-Hydroxy-pregnan-20-one
Molecular Weight:	318.49

View Full Technical Details for Pregnanolone

Technical Data
Citations

Biological Activity for Pregnanolone

Pregnanolone is a GABA_A receptor positive allosteric modulator. Neuroactive steroid.

Technical Data for Pregnanolone

M. Wt	318.49
Formula	C₂₁H₃₄O₂
Storage	Store at RT
CAS Number	128-20-1
PubChem ID	31402
InChi Key	AURFZBICLPNKBZ-YZRLXODZSA-N
Smiles	C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pregnanolone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.85	100
	ethanol	31.85	100

Preparing Stock Solutions for Pregnanolone

The following data is based on the product molecular weight 318.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.70 mL	31.40 mL
5 mM	0.63 mL	3.14 mL	6.28 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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Reconstitution Calculator

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References for Pregnanolone

References are publications that support the biological activity of the product.

Morris Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 1999 PMID: 10496958
Harrison Structure-activity relationships for steroid interaction with the γ-aminobutyric acid_A receptor complex. J.Pharmacol.Exp.Ther. 1987 PMID: 3033209