PPM-3
Tocris Bioscience, part of Bio-Techne | Catalog # 8116
Potent and selective ERK5 Degrader (PROTAC®)
Key Product Details
Description
Potent and selective ERK5 Degrader (PROTAC®)
Product Description
PPM-3 is a potent and selective ERK5 Degrader (PROTAC®) (IC50 = 62.4 nM). PPM-3 degrades ERK5 in HCT116, h1975, HepG2, MDA-MB-231, PC-3, and A375 tumor cell lines (DC50 values are 5.6, 11.5, 13.7, 22.7, 23.5 and 41.4 nM respectively). PPM-3 has no effect on tumor cell growth directly but influences tumor development by affecting the differentiation of macrophages.Product Specifications
Molecular Weight
1000.28
Formula
C54H69N11O6S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-(7-(4-(4-((5,11-Dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
CAS Number
3032388-42-1
PubChem ID
168679766
InChI Key
QGJQNPNZAYRDMS-OESUUHGFSA-N
SMILES
O=C1C2=CC=CC=C2N(C3=NC(NC4=CC=C(N5CCN(CCCCCCC(N[C@H](C(N6C[C@H](O)C[C@H]6C(N[C@@H](C)C7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)C(C)(C)C)=O)CC5)C=C4OC)=NC=C3N1C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.03 | 100 |
Preparing Stock Solutions
for PPM-3
The following data is based on the product molecular weight 1000.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.00 mL | 5.00 mL | 10.00 mL |
| 5 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 10 mM | 0.10 mL | 0.50 mL | 1.00 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for PPM-3
For research use only
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