PP 2

Tocris Bioscience, part of Bio-Techne | Catalog # 1407

Potent, selective Src family kinase inhibitor
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Key Product Details

Description

Potent, selective Src family kinase inhibitor

View all Src Family Kinase Inhibitors »

Product Description

PP 2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).

Negative Control also available.

Product Specifications

Molecular Weight

301.78

Formula

C15H16ClN5

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS Number

172889-27-9

PubChem ID

4878

InChI Key

PBBRWFOVCUAONR-UHFFFAOYSA-N

SMILES

CC(C)(C)N1N=C(C2=C(N)N=CN=C12)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25 with gentle warming
Ethanol 10 with gentle warming

Preparing Stock Solutions for PP 2

The following data is based on the product molecular weight 301.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.25 mL 66.27 mL 132.55 mL
1.25 mM 2.65 mL 13.25 mL 26.51 mL
2.5 mM 1.33 mL 6.63 mL 13.25 mL
12.5 mM 0.27 mL 1.33 mL 2.65 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PP 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PP 2

For research use only

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