PP 1

Tocris Bioscience, part of Bio-Techne | Catalog # 1397

Potent, selective Src family kinase inhibitor
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Key Product Details

Description

Potent, selective Src family kinase inhibitor

View all Src Family Kinase Inhibitors »

Product Description

PP 1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.

Product Specifications

Molecular Weight

281.36

Formula

C16H19N5

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS Number

172889-26-8

PubChem ID

1400

InChI Key

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

SMILES

CC1=CC=C(C=C1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10
Ethanol 10

Preparing Stock Solutions for PP 1

The following data is based on the product molecular weight 281.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.54 mL 177.71 mL 355.42 mL
0.5 mM 7.11 mL 35.54 mL 71.08 mL
1 mM 3.55 mL 17.77 mL 35.54 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PP 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PP 1

For research use only

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