POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y₁₂ (K_i values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y₁₂ and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Product Specifications

Molecular Weight

2986.01

Formula

H₂O₄₀Na₆W₁₂

Storage

Store at RT

Chemical Name

Sodium metatungstate

CAS Number

12141-67-2

PubChem ID

71311259

InChI Key

YVQUUPJGDSQKML-UHFFFAOYSA-N

SMILES

O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	298.6	100

Preparing Stock Solutions for POM 1

The following data is based on the product molecular weight 2986.01

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.33 mL	1.67 mL	3.35 mL
5 mM	0.07 mL	0.33 mL	0.67 mL
10 mM	0.03 mL	0.17 mL	0.33 mL
50 mM	0.01 mL	0.03 mL	0.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Grenz Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 2007 PMID: 17442731
Muller Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 2006 PMID: 16997558

POM 1

Tocris Bioscience, part of Bio-Techne | Catalog # 2689

Key Product Details

Description

Alternative Names

View all NTPDase Inhibitors »

Product Description