PMX 205

Tocris Bioscience, part of Bio-Techne | Catalog # 5196

COA / SDS

Potent C5a receptor peptide antagonist

Key Product Details

Description:	Potent C5a receptor peptide antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	839.05

View Full Technical Details for PMX 205

Technical Data
Citations

Biological Activity for PMX 205

PMX 205 is a potent C5a receptor peptide antagonist (IC₅₀ = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Technical Data for PMX 205

M. Wt	839.05
Formula	C₄₅H₆₂N₁₀O₆
Single Letter Sequence	XPXWR (Modifications: X-1 = N²-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	514814-49-4
PubChem ID	90489023
InChi Key	YUIBSMOWXFHTBD-UHFFFAOYSA-N
Smiles	NC(=N)NCCCC1NC(=O)C(CC2C=NC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C(=O)C(CCCNC1=O)NC(=O)CCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PMX 205

Solubility

Soluble to 1mg/ml in water with sonication

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References for PMX 205

References are publications that support the biological activity of the product.

Kumar Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Sci.Rep. 2018 PMID: 29802264
Lee Pharmacological inhibition of complement C5a-C5a₁ receptor signalling ameliorates disease pathology in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Br.J.Pharmacol. 2017 PMID: 28128456
Fonseca Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J.Immunol. 2009 PMID: 19561098
Jain The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br.J.Pharmacol. 2013 PMID: 22924972
March Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol.Pharmacol. 2004 PMID: 15044616