(+)-Tubocurarine chloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2820
nAChR antagonist
Key Product Details
Description
nAChR antagonist
Product Description
(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.Product Specifications
Molecular Weight
681.65
Formula
C37H41ClN2O6.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
CAS Number
57-94-3
PubChem ID
64645
InChI Key
GXFZCDMWGMFGFL-KKXMJGKMSA-N
SMILES
OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.04 | 25 |
Preparing Stock Solutions
for (+)-Tubocurarine chloride
The following data is based on the product molecular weight 681.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 5.87 mL | 29.34 mL | 58.68 mL |
| 1.25 mM | 1.17 mL | 5.87 mL | 11.74 mL |
| 2.5 mM | 0.59 mL | 2.93 mL | 5.87 mL |
| 12.5 mM | 0.12 mL | 0.59 mL | 1.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Peters Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts.
- Wotring and Yoon The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci.
- Pederson and Cohen d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA
Product Specific Notices for (+)-Tubocurarine chloride
For research use only
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