(+)-SK&F 10047 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1079
σ1 selective agonist
Product Description
(+)-SK&F 10047 hydrochloride is a prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.Product Specifications
Molecular Weight
293.84
Formula
C17H23NO.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
CAS Number
133005-41-1
PubChem ID
16759596
InChI Key
ZTGMHFIGNYXMJV-XSCGHNKWSA-N
SMILES
Cl.C[C@@H]1[C@@H]2CC3=CC=C(O)C=C3[C@@]1(C)CCN2CC=C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.38 | 100 | |
| DMSO | 29.38 | 100 |
Preparing Stock Solutions
for (+)-SK&F 10047 hydrochloride
The following data is based on the product molecular weight 293.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.40 mL | 17.02 mL | 34.03 mL |
| 5 mM | 0.68 mL | 3.40 mL | 6.81 mL |
| 10 mM | 0.34 mL | 1.70 mL | 3.40 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Matsuno Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 1995 PMID: 8535837
- Walker Sigma receptors: biology and function. Pharmacol.Rev. 1990 PMID: 1964225
- Kamei (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 1996 PMID: 8874133
Product Specific Notices for (+)-SK&F 10047 hydrochloride
For research use only
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