(+)-PD 128907 hydrochloride

Name: (+)-PD 128907 hydrochloride
Brand: Tocris Bioscience
SKU: 1243

Tocris Bioscience, part of Bio-Techne | Catalog # 1243

Citations (12)

COA / SDS

High affinity D3 agonist (D3 ≥ D2 > D4)

Key Product Details

Description:	High affinity D₃ agonist (D₃ ≥ D₂ > D₄)
Chemical Name:	(4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	285.77

View Full Technical Details for (+)-PD 128907 hydrochloride

Technical Data
Citations

Biological Activity for (+)-PD 128907 hydrochloride

(+)-PD 128907 hydrochloride is a high affinity D₃ dopamine receptor agonist (K_i = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.

Technical Data for (+)-PD 128907 hydrochloride

M. Wt	285.77
Formula	C₁₄H₁₉NO₃.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	300576-59-4
PubChem ID	11957668
InChi Key	DCFXOTRONMKUJB-QMDUSEKHSA-N
Smiles	CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-PD 128907 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	2.86	10

Preparing Stock Solutions for (+)-PD 128907 hydrochloride

The following data is based on the product molecular weight 285.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.99 mL	174.97 mL	349.93 mL
0.5 mM	7.00 mL	34.99 mL	69.99 mL
1 mM	3.50 mL	17.50 mL	34.99 mL
5 mM	0.70 mL	3.50 mL	7.00 mL

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References for (+)-PD 128907 hydrochloride

References are publications that support the biological activity of the product.

Pugsley Neurochemical and functional characterization of the preferentially selective DA D₃ agonist PD 128907. J.Pharmacol.Exp.Ther. 1995 PMID: 8531103
Witkin Atypical antipsychotic-like effects of the DA D₃ receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 1998 PMID: 9741997
Bristow The behavioural and neurochemical profile of the putative DA D₃ receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 1996 PMID: 8783203