(+)-Igmesine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2332
Selective σ1 ligand; antidepressant
Key Product Details
Description
Selective σ1 ligand; antidepressant
Product Description
(+)-Igmesine hydrochloride is a selective σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
355.94
Formula
C23H29N.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride
CAS Number
130152-35-1
PubChem ID
6438339
InChI Key
SCHQQPAJNUHKSV-RSGUCCNWSA-N
SMILES
CN(C(CC)(C3=CC=CC=C3)C/C=C/C2=CC=CC=C2)CC1CC1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.8 | 50 |
Preparing Stock Solutions
for (+)-Igmesine hydrochloride
The following data is based on the product molecular weight 355.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.62 mL | 28.09 mL | 56.19 mL |
| 2.5 mM | 1.12 mL | 5.62 mL | 11.24 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.62 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- O'Neill The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol. 1995 PMID: 7498313
- Akunne Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology 2001 PMID: 11445194
Product Specific Notices for (+)-Igmesine hydrochloride
For research use only
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