(+)-Anabasine hydrochloride

Name: (+)-Anabasine hydrochloride
Brand: Tocris Bioscience
SKU: 1971

Catalog # 1971 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

High affinity nAChR partial agonist

Key Product Details

Description:	High affinity nAChR partial agonist
Chemical Name:	(S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	198.69

View Full Technical Details for (+)-Anabasine hydrochloride

Technical Data
Citations / Reviews

Biological Activity for (+)-Anabasine hydrochloride

(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (K_i values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca²⁺-dependent catecholamine release from rat adrenomedullary cells in vitro.

Technical Data for (+)-Anabasine hydrochloride

M. Wt	198.69
Formula	C₁₀H₁₄N₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	53912-89-3
PubChem ID	3041330
InChi Key	VTMZQNZVYCJLGG-PPHPATTJSA-N
Smiles	[C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Anabasine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.87	100

Preparing Stock Solutions for (+)-Anabasine hydrochloride

The following data is based on the product molecular weight 198.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.03 mL	25.16 mL	50.33 mL
5 mM	1.01 mL	5.03 mL	10.07 mL
10 mM	0.50 mL	2.52 mL	5.03 mL
50 mM	0.10 mL	0.50 mL	1.01 mL

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References for (+)-Anabasine hydrochloride

References are publications that support the biological activity of the product.

Hong Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 2007 PMID: 18186309
Lu Desensitization of nicotinic agonist-induced [³H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 1999 PMID: 10565833
Parker Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 1998 PMID: 9855644
Kem Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 9399967

Citations for (+)-Anabasine hydrochloride

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