(+)-Anabasine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1971
High affinity nAChR partial agonist
Discontinued Product
1971 has been discontinued.
View all Additional Nicotinic Receptor Agonists products.
Key Product Details
Description
High affinity nAChR partial agonist
Product Description
(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (Ki values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro.Product Specifications
Molecular Weight
198.69
Formula
C10H14N2.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
(S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
CAS Number
53912-89-3
PubChem ID
3041330
InChI Key
VTMZQNZVYCJLGG-PPHPATTJSA-N
SMILES
[C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.87 | 100 |
Preparing Stock Solutions
for (+)-Anabasine hydrochloride
The following data is based on the product molecular weight 198.69
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.03 mL | 25.16 mL | 50.33 mL |
| 5 mM | 1.01 mL | 5.03 mL | 10.07 mL |
| 10 mM | 0.50 mL | 2.52 mL | 5.03 mL |
| 50 mM | 0.10 mL | 0.50 mL | 1.01 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hong Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 2007 PMID: 18186309
- Parker Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 1998 PMID: 9855644
- Lu Desensitization of nicotinic agonist-induced [3H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 1999 PMID: 10565833
- Kem Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 9399967
Product Specific Notices for (+)-Anabasine hydrochloride
For research use only
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