PluriSln 1

Name: PluriSln 1
Brand: Tocris Bioscience
SKU: 4847

Tocris Bioscience, part of Bio-Techne | Catalog # 4847

COA / SDS

SCD-1 inhibitor

Key Product Details

Description:	SCD-1 inhibitor
Alternative Names:	NSC 14613
Chemical Name:	4-Pyridinecarboxylic acid 2-phenylhydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	213.24

View Full Technical Details for PluriSln 1

Technical Data
Citations

Biological Activity for PluriSln 1

PluriSln 1 is a stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.

Compound Libraries for PluriSln 1

PluriSln 1 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for PluriSln 1

M. Wt	213.24
Formula	C₁₂H₁₁N₃O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	91396-88-2
PubChem ID	225362
InChi Key	HUDWXDLBWRHCKO-UHFFFAOYSA-N
Smiles	O=C(NNC2=CC=CC=C2)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PluriSln 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.32	100
	ethanol	21.32	100

Preparing Stock Solutions for PluriSln 1

The following data is based on the product molecular weight 213.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.69 mL	23.45 mL	46.90 mL
5 mM	0.94 mL	4.69 mL	9.38 mL
10 mM	0.47 mL	2.34 mL	4.69 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

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Reconstitution Calculator

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References for PluriSln 1

References are publications that support the biological activity of the product.

Ben-David Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 2013 PMID: 23318055