PIT 1

Name: PIT 1
Brand: Tocris Bioscience
SKU: 4168
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4168

(1)

Citations (12)

COA / SDS

PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling

Discontinued Product

4168 has been discontinued. View all Inositol Lipid Antagonists products.

Key Product Details

Description:	PIP₃ antagonist. Blocks PIP₃-PH interaction; inhibits Akt signaling
Chemical Name:	N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	351.76

View Full Technical Details for PIT 1

Technical Data
Citations / Reviews (1)

Biological Activity for PIT 1

PIT 1 is a selective PIP₃ antagonist. Blocks the binding of PIP₃ to the pleckstrin homology (PH) domain of Akt (IC₅₀ = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP₃-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.

Technical Data for PIT 1

M. Wt	351.76
Formula	C₁₄H₁₀ClN₃O₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	53501-41-0
PubChem ID	3664359
InChi Key	RIGXBXPAOGDDIG-UHFFFAOYSA-N
Smiles	ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PIT 1

References are publications that support the biological activity of the product.

Miao Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP₃) binding to pleckstrin homology domains. Proc.Natl.Acad.Sci.

PIT 1

Tocris Bioscience, part of Bio-Techne | Catalog # 4168

Key Product Details

Biological Activity for PIT 1

Technical Data for PIT 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PIT 1

Product Documents for PIT 1

COA

Certificate of Analysis

SDS

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