Pifithrin-μ

Name: Pifithrin- μ
Brand: Tocris Bioscience
SKU: 2653
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2653

(1)

Citations (4)

COA / SDS

Inhibitor of p53-mitochondrial binding

Key Product Details

Description:	Inhibitor of p53-mitochondrial binding
Alternative Names:	NSC 303580
Chemical Name:	2-Phenylethynesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	181.21

View Full Technical Details for Pifithrin-μ

Technical Data
Citations / Reviews (1)

Biological Activity for Pifithrin-μ

Pifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Technical Data for Pifithrin-μ

M. Wt	181.21
Formula	C₈H₇NO₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	64984-31-2
PubChem ID	327653
InChi Key	ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Smiles	NS(=O)(=O)C#CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pifithrin-μ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	13.12	100
	ethanol	13.12	100

Preparing Stock Solutions for Pifithrin-μ

The following data is based on the product molecular weight 181.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.52 mL	27.59 mL	55.18 mL
5 mM	1.10 mL	5.52 mL	11.04 mL
10 mM	0.55 mL	2.76 mL	5.52 mL
50 mM	0.11 mL	0.55 mL	1.10 mL

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Reconstitution Calculator

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References for Pifithrin-μ

References are publications that support the biological activity of the product.

Steele 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 2009 PMID: 19515722
Leu A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 2009 PMID: 19818706
Kawamura Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 2009 PMID: 19668186
Strom Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2006 PMID: 16862141