Picropodophyllotoxin
Tocris Bioscience, part of Bio-Techne | Catalog # 2956
Selective IGF1R inhibitor
Key Product Details
Description
Selective IGF1R inhibitor
Alternative Names
Picropodophyllin
Product Description
Picropodophyllotoxin is an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.Product Specifications
Molecular Weight
414.41
Formula
C22H22O8
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furonaphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CAS Number
477-47-4
PubChem ID
72435
InChI Key
YJGVMLPVUAXIQN-HAEOHBJNSA-N
SMILES
O=C3OC[C@]([C@@]([H])3[C@@H]4[C@]5=CC(OC)=C(OC)C(OC)=C5)([H])[C@@H](O)C1=C4C=C(OCO2)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 100 |
Preparing Stock Solutions
for Picropodophyllotoxin
The following data is based on the product molecular weight 414.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stromberg IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 2006 PMID: 16166596
- Economou Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the Ins-like growth factor-1 receptor. Invest.Ophthalmol.Vis.Sci. 2008 PMID: 18515591
- Girnita Cyclolignans as inhibitors of the Ins-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 PMID: 14729630
Product Specific Notices for Picropodophyllotoxin
For research use only
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