Piclamilast

Tocris Bioscience, part of Bio-Techne | Catalog # 4525

Potent and selective PDE4 inhibitor
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Key Product Details

Description

Potent and selective PDE4 inhibitor

Alternative Names

RP 73401

View all Phosphodiesterase Inhibitors »

Product Description

Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).

Product Specifications

Molecular Weight

381.25

Formula

C18H18Cl2N2O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide

CAS Number

144035-83-6

PubChem ID

154575

InChI Key

RRRUXBQSQLKHEL-UHFFFAOYSA-N

SMILES

O=C(NC3=C(Cl)C=NC=C3Cl)C1=CC(OC2CCCC2)=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.12 100

Preparing Stock Solutions for Piclamilast

The following data is based on the product molecular weight 381.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.23 mL
5 mM 0.52 mL 2.62 mL 5.25 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Piclamilast

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Piclamilast

For research use only

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