Piceatannol
Tocris Bioscience, part of Bio-Techne | Catalog # 1554
Inhibits TNF-induced NF-κB activation
Discontinued Product
1554 has been discontinued.
View all NFkB/IkB Inhibitors products.
Key Product Details
Description
Inhibits TNF-induced NF-κB activation
Product Description
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.Product Specifications
Molecular Weight
244.25
Formula
C14H12O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
CAS Number
10083-24-6
PubChem ID
667639
InChI Key
CDRPUGZCRXZLFL-OWOJBTEDSA-N
SMILES
OC1=CC(\C=C\C2=CC(O)=C(O)C=C2)=CC(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.43 | 100 | |
| Ethanol | 24.43 | 100 |
Preparing Stock Solutions
for Piceatannol
The following data is based on the product molecular weight 244.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.94 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Potter The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 2002 PMID: 11875742
- Geahlen and McLaughlin Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 1989 PMID: 2590224
- Oliver Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 1994 PMID: 7961959
- Ashikawa Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 2002 PMID: 12444159
Product Specific Notices for Piceatannol
For research use only
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