PHTPP
Tocris Bioscience, part of Bio-Techne | Catalog # 2662
Selective ERβ antagonist
Key Product Details
Description
Selective ERβ antagonist
Product Description
PHTPP is a selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα.Product Specifications
Molecular Weight
423.31
Formula
C20H11F6N3O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
CAS Number
805239-56-9
PubChem ID
11201035
InChI Key
AEZPAUSGTAHLOQ-UHFFFAOYSA-N
SMILES
OC1=CC=C(C=C1)C1=C2N=C(C=C(N2N=C1C1=CC=CC=C1)C(F)(F)F)C(F)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.96 | 33 | |
| Ethanol | 42.33 | 100 |
Preparing Stock Solutions
for PHTPP
The following data is based on the product molecular weight 423.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.36 mL | 11.81 mL | 23.62 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Compton Erratum. J.Med.Chem.
- Compton Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity. J.Med.Chem. 2004 PMID: 15537344
Product Specific Notices for PHTPP
For research use only
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