PHTPP

Name: PHTPP
Brand: Tocris Bioscience
SKU: 2662

Tocris Bioscience, part of Bio-Techne | Catalog # 2662

Citations (267)

COA / SDS

Selective ERβ antagonist

Key Product Details

Description:	Selective ERβ antagonist
Chemical Name:	4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
Purity:	≥98% (HPLC)
Molecular Weight:	423.31

View Full Technical Details for PHTPP

Technical Data
Citations

Biological Activity for PHTPP

PHTPP is a selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα.

Compound Libraries for PHTPP

PHTPP is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PHTPP

M. Wt	423.31
Formula	C₂₀H₁₁F₆N₃O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	805239-56-9
PubChem ID	11201035
InChi Key	AEZPAUSGTAHLOQ-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=C2N=C(C=C(N2N=C1C1=CC=CC=C1)C(F)(F)F)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PHTPP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	13.96	33
	ethanol	42.33	100

Preparing Stock Solutions for PHTPP

The following data is based on the product molecular weight 423.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.36 mL	11.81 mL	23.62 mL
5 mM	0.47 mL	2.36 mL	4.72 mL
10 mM	0.24 mL	1.18 mL	2.36 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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Reconstitution Calculator

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References for PHTPP

References are publications that support the biological activity of the product.

Compton Erratum. J.Med.Chem.
Compton Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor β antagonist activity. J.Med.Chem. 2004 PMID: 15537344