Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.

Product Specifications

Molecular Weight

279.85

Formula

C₁₇H₂₅N.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-(1-Phenylcyclohexyl)piperidine hydrochloride

CAS Number

956-90-1

PubChem ID

13727

InChI Key

BUAJNGPDPGKBGV-UHFFFAOYSA-N

SMILES

N2(CCCCC2)C1(C3=CC=CC=C3)CCCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	11.19	40

Preparing Stock Solutions for Phencyclidine hydrochloride

The following data is based on the product molecular weight 279.85

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.4 mM	8.93 mL	44.67 mL	89.33 mL
2 mM	1.79 mL	8.93 mL	17.87 mL
4 mM	0.89 mL	4.47 mL	8.93 mL
20 mM	0.18 mL	0.89 mL	1.79 mL

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Background References

References are publications that support the biological activity of the product.

Jin The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine. Eur.J.Pharmacol. 1997 PMID: 9042584
Sharp Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression. Brain Res. 1997 PMID: 9203533
Linders Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c J.Med.Chem. 1993 PMID: 8355251

Phencyclidine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2557

Key Product Details

Description

Alternative Names

View all NMDA Receptor Antagonists »

Product Description