PF 915275

Tocris Bioscience, part of Bio-Techne | Catalog # 3291

Potent and selective 11β-hydroxysteroid dehydrogenase inhibitor
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Key Product Details

Description

Potent and selective 11β-hydroxysteroid dehydrogenase inhibitor

View all 11 beta-HSD Inhibitors »

Product Description

PF 915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10 μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. Orally active.

Product Specifications

Molecular Weight

350.39

Formula

C18H14N4O2S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

CAS Number

857290-04-1

PubChem ID

23725123

InChI Key

ZESFDAKNYJQYKO-UHFFFAOYSA-N

SMILES

NC1=NC(NS(C(C=C3)=CC=C3C2=CC=C(C#N)C=C2)(=O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.04 100

Preparing Stock Solutions for PF 915275

The following data is based on the product molecular weight 350.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.54 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Calculators

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Product Documents for PF 915275

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 915275

For research use only

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