PF 4981517

Name: PF 4981517
Brand: Tocris Bioscience
SKU: 4252

Tocris Bioscience, part of Bio-Techne | Catalog # 4252

COA / SDS

Selective CYP3A4 inhibitor

Discontinued Product

4252 has been discontinued. View all Cytochrome P450 Inhibitors products.

Key Product Details

Description:	Selective CYP3A4 inhibitor
Chemical Name:	(1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)
Purity:	≥98% (HPLC)
Molecular Weight:	456.59

View Full Technical Details for PF 4981517

Technical Data
Citations

Biological Activity for PF 4981517

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC₅₀ values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 4981517

M. Wt	456.59
Formula	C₂₆H₃₂N₈
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1390637-82-7
PubChem ID	71315139
InChi Key	WDWIMDKOXZZYHH-FQEVSTJZSA-N
Smiles	CN1N=C(C5=C(C6=CC=C(C)C=C6)N(C)N=C5)C2=C1N=CN=C2N3C[C@@H](N4CCCCC4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PF 4981517

References are publications that support the biological activity of the product.

Walsky Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Am.Soc.Pharmacol.Exp.Ther.