PF 4708671
Tocris Bioscience, part of Bio-Techne | Catalog # 4032
S6K1 inhibitor
Product Description
PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
390.41
Formula
C19H21F3N6
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
CAS Number
1255517-76-0
PubChem ID
51371303
InChI Key
FBLPQCAQRNSVHB-UHFFFAOYSA-N
SMILES
CCC(C=NC=N2)=C2N1CCN(CC4=NC3=CC(C(F)(F)F)=CC=C3N4)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.52 | 50 | |
| Ethanol | 19.52 | 50 |
Preparing Stock Solutions
for PF 4708671
The following data is based on the product molecular weight 390.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.12 mL | 25.61 mL | 51.23 mL |
| 2.5 mM | 1.02 mL | 5.12 mL | 10.25 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 25 mM | 0.10 mL | 0.51 mL | 1.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pearce Characterisation of PF-4708671 a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem.J. 2010 PMID: 20704563
Product Specific Notices for PF 4708671
For research use only
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