PF 431396
Tocris Bioscience, part of Bio-Techne | Catalog # 4278
Dual FAK/PYK2 inhibitor
Product Description
PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
506.50
Formula
C22H21F3N6O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
CAS Number
717906-29-1
PubChem ID
11598628
InChI Key
POJZIZBONPAWIV-UHFFFAOYSA-N
SMILES
O=C2NC1=CC=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC=C4N(C)S(=O)(C)=O)=N3)C=C1C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.32 | 50 |
Preparing Stock Solutions
for PF 431396
The following data is based on the product molecular weight 506.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.95 mL | 19.74 mL | 39.49 mL |
| 2.5 mM | 0.79 mL | 3.95 mL | 7.90 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Han Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem. 2009 PMID: 19244237
- Allen Emerging targets in osteoporosis disease modification. J.Med.Chem. 2010 PMID: 20218623
- Buckbinder Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc.Natl.Acad.Sci.USA 2007 PMID: 17537919
Product Specific Notices for PF 431396
For research use only
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