PF 06409577

Name: PF 06409577
Brand: Tocris Bioscience
SKU: 6114

Tocris Bioscience, part of Bio-Techne | Catalog # 6114

Citations (3)

COA / SDS

Potent and selective allosteric activator of AMPK

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Product Description
Licensing Information
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective allosteric activator of AMPK

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Product Description

PF 06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

341.79

Formula

C₁₉H₁₆ClNO₃

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid

CAS Number

1467057-23-3

PubChem ID

71748255

InChI Key

FHQXLWCFSUSXBF-UHFFFAOYSA-N

SMILES

O=C(O)C1=CNC2=CC(Cl)=C(C3=CC=C(C4(CCC4)O)C=C3)C=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.18	100
	Ethanol	6.84	20

Preparing Stock Solutions for PF 06409577

The following data is based on the product molecular weight 341.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.63 mL	29.26 mL
5 mM	0.59 mL	2.93 mL	5.85 mL
10 mM	0.29 mL	1.46 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Salatto Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathy. J.Pharmacol.Exp.Ther. 2017 PMID: 28289077
Cameron Discovery and preclinical characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a direct activator of adenosine monophosphate-activated protein kinase (AMPK), for the potential treatment of diab J.Med.Chem. 2016 PMID: 27490827