PF 05190457

Tocris Bioscience, part of Bio-Techne | Catalog # 6350

High affinity and selective ghrelin receptor inverse agonist
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Key Product Details

Description

High affinity and selective ghrelin receptor inverse agonist

View all Ghrelin Receptor Inverse Agonists »

Product Description

PF 05190457 is a high affinity and selective ghrelin receptor inverse agonist (Kd = 3 nM). Exhibits selectivity for ghrelin receptors over a panel of other targets. Increases intracellular Ca2+ concentration in and insulin secretion from human islets in vitro. Increases gastric afferent nerve activity in a rat ex vivo stomach preparation.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications

Molecular Weight

512.67

Formula

C29H32N6OS

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[2-[(1R)-2,3-Dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3,5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone

CAS Number

1334782-79-4

PubChem ID

58438464

InChI Key

ZIUDADZJCKGWKR-AREMUKBSSA-N

SMILES

CC1=CC(C2=CC(CC[C@H]3N4CC5(CCN(C(CC6=CN7C(SC(C)=C7)=N6)=O)CC5)C4)=C3C=C2)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.56 5 with gentle warming
Ethanol 5.13 10 with gentle warming

Preparing Stock Solutions for PF 05190457

The following data is based on the product molecular weight 512.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.51 mL 97.53 mL 195.06 mL
0.5 mM 3.90 mL 19.51 mL 39.01 mL
1 mM 1.95 mL 9.75 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.90 mL

Calculators

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Product Documents for PF 05190457

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 05190457

For research use only

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