PF 04671536 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6024
Potent and selective PDE8B/8A inhibitor
Key Product Details
Description
Potent and selective PDE8B/8A inhibitor
Product Description
PF 04671536 hydrochloride is a potent and selective PDE8B/8A inhibitor (IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
382.87
Formula
C14H18N8OS.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5-Methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine hydrochloride
CAS Number
1305116-67-9
PubChem ID
131954582
InChI Key
KNBIGIZPAKPDTF-HNCPQSOCSA-N
SMILES
CC1=NC(N)=C2N=NN(C2=N1)C[C@H]3CN(CCO3)CC4=NC=CS4.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.66 | 20 with gentle warming | |
| DMSO | 38.29 | 100 |
Preparing Stock Solutions
for PF 04671536 hydrochloride
The following data is based on the product molecular weight 382.87
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.06 mL | 26.12 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- DeNinno Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 2012 PMID: 22858141
Product Specific Notices for PF 04671536 hydrochloride
For research use only
Loading...
Loading...