PF 04620110
Tocris Bioscience, part of Bio-Techne | Catalog # 5863
Potent and selective DGAT-1 inhibitor; orally bioavailable
Key Product Details
Description
Potent and selective DGAT-1 inhibitor; orally bioavailable
Product Description
PF 04620110 is a potent and selective DGAT-1 inhibitor (IC50 = 19 nM). Exhibits >1000-fold selectivity for DGAT-1 over DGAT-2, and no significant activity against a range of other enzymes, ion channels and receptors. Reduces plasma triglyceride levels in a rat lipid challenge model. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
396.44
Formula
C21H24N4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
trans-4-[4-(4-Amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexaneacetic acid
CAS Number
1109276-89-2
PubChem ID
46926360
InChI Key
GEVVQZHMFVFGLN-UHFFFAOYSA-N
SMILES
O=C1N(C2=CC=C([C@@H]3CC[C@@H](CC(O)=O)CC3)C=C2)CCOC4=NC=NC(N)=C41
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.93 | 20 |
Preparing Stock Solutions
for PF 04620110
The following data is based on the product molecular weight 396.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.61 mL | 63.06 mL | 126.12 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 2 mM | 1.26 mL | 6.31 mL | 12.61 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dow Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1. ACS Med.Chem.Lett. 2011 PMID: 24900321
Product Specific Notices for PF 04620110
For research use only
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