Pertussis Toxin
Tocris Bioscience, part of Bio-Techne | Catalog # 3097
Catalyzes ADP-ribosylation of Gi, Go and Gt
Key Product Details
Description
Catalyzes ADP-ribosylation of Gi, Go and Gt
Product Description
Pertussis Toxin is a bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling. Pertussis Toxin protects against ischemic stroke in a mouse model of permanent middle cerebral artery occlusion. Pertussis Toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an experimental autoimmune encephalomyelitis mouse model.Product Specifications
Storage
Store at +4°C
CAS Number
70323-44-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Background References
References are publications that support the biological activity of the product.
- Yin Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model. PLoS One 2010 PMID: 20811645
- Tang Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model. J.Neurochem. 2015 PMID: 26365274
- Barbieri and Cortina ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect.Immun. 1988 PMID: 3135265
- Casey G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa. Biochemistry 1989 PMID: 2496748
- Bokoch Indentification of the predominant substrate for ADP-ribosylation by islet activating protein. J.Biol.Chem. 1983 PMID: 6296122
Product Specific Notices for Pertussis Toxin
For research use only
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