Perlapine

Name: Perlapine
Brand: Tocris Bioscience
SKU: 5549

Tocris Bioscience, part of Bio-Techne | Catalog # 5549

Citations (4)

COA / SDS

Potent hM3Dq and hM4Di DREADD agonist in vitro

Key Product Details

Description:	Potent hM₃D_q and hM₄D_i DREADD agonist in vitro
Chemical Name:	6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Purity:	≥99% (HPLC)
Molecular Weight:	291.39

View Full Technical Details for Perlapine

Technical Data
Citations

Biological Activity for Perlapine

Perlapine is a potent muscarinic DREADD agonist (pEC₅₀ values are 8.38, 8.08 and 7.27 for hM₁D_q, hM₃D_q and hM₄D_i in vitro, respectively). Exhibits >10,000-fold selectivity for hM₃D_q over hM₃ receptors.

Technical Data for Perlapine

M. Wt	291.39
Formula	C₁₉H₂₁N₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1977-11-3
PubChem ID	16106
InChi Key	PWRPUAKXMQAFCJ-UHFFFAOYSA-N
Smiles	CN(CC4)CCN4C1=NC(C=CC=C3)=C3CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Perlapine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	14.57	50
	water	1.46	5 with gentle warming

Preparing Stock Solutions for Perlapine

The following data is based on the product molecular weight 291.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.86 mL	34.32 mL	68.64 mL
2.5 mM	1.37 mL	6.86 mL	13.73 mL
5 mM	0.69 mL	3.43 mL	6.86 mL
25 mM	0.14 mL	0.69 mL	1.37 mL

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References for Perlapine

References are publications that support the biological activity of the product.

Thompson DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo. ACS Pharmacol.Transl.Sci. 2018 PMID: 30868140
Chen The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 2015 PMID: 25587888