Pepstatin A
Tocris Bioscience, part of Bio-Techne | Catalog # 1190
Selective and high affinity cathepsin D inhibitor
Key Product Details
Description
Selective and high affinity cathepsin D inhibitor
Product Description
Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).Product Specifications
Molecular Weight
685.91
Formula
C34H63N5O9
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
26305-03-3
PubChem ID
5478883
InChI Key
FAXGPCHRFPCXOO-LXTPJMTPSA-N
SMILES
O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in Ethanol with gentle warming |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mizuochi Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. Immunol.Lett. 1997 PMID: 7721331
- Sato Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 2007 PMID: 17942897
- Gacko Cathepsin D inhibitors. Folia Histochem.Cytobiol. 2007 PMID: 18165168
- Marciniszyn Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 1976 PMID: 993206
Product Specific Notices for Pepstatin A
For research use only
Loading...
Loading...
Loading...