Pentylenetetrazole
Tocris Bioscience, part of Bio-Techne | Catalog # 2687
CNS stimulant
Key Product Details
Description
CNS stimulant
Alternative Names
PTZ
Product Description
Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.Product Specifications
Molecular Weight
138.17
Formula
C6H10N4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
CAS Number
54-95-5
PubChem ID
5917
InChI Key
CWRVKFFCRWGWCS-UHFFFAOYSA-N
SMILES
C1CCN2N=NN=C2CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.81 | 100 | |
| DMSO | 13.81 | 100 |
Preparing Stock Solutions
for Pentylenetetrazole
The following data is based on the product molecular weight 138.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.24 mL | 36.19 mL | 72.37 mL |
| 5 mM | 1.45 mL | 7.24 mL | 14.47 mL |
| 10 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 50 mM | 0.14 mL | 0.72 mL | 1.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Walsh Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 1999 PMID: 10336561
- Dhir Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat.
- Rocha Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 1996 PMID: 8985692
Product Specific Notices for Pentylenetetrazole
For research use only
Loading...
Loading...
Loading...