Pentylenetetrazole

Name: Pentylenetetrazole
Brand: Tocris Bioscience
SKU: 2687
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2687

(1)

Citations (9)

COA / SDS

CNS stimulant

Key Product Details

Description:	CNS stimulant
Alternative Names:	PTZ
Chemical Name:	6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Purity:	≥98% (HPLC)
Molecular Weight:	138.17

View Full Technical Details for Pentylenetetrazole

Technical Data
Citations / Reviews (1)

Biological Activity for Pentylenetetrazole

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data for Pentylenetetrazole

M. Wt	138.17
Formula	C₆H₁₀N₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	54-95-5
PubChem ID	5917
InChi Key	CWRVKFFCRWGWCS-UHFFFAOYSA-N
Smiles	C1CCN2N=NN=C2CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pentylenetetrazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.81	100
	DMSO	13.81	100

Preparing Stock Solutions for Pentylenetetrazole

The following data is based on the product molecular weight 138.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.24 mL	36.19 mL	72.37 mL
5 mM	1.45 mL	7.24 mL	14.47 mL
10 mM	0.72 mL	3.62 mL	7.24 mL
50 mM	0.14 mL	0.72 mL	1.45 mL

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Reconstitution Calculator

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References for Pentylenetetrazole

References are publications that support the biological activity of the product.

Walsh Acute pentylenetetrazol injection reduces rat GABA_A receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 1999 PMID: 10336561
Dhir Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat.
Rocha Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 1996 PMID: 8985692