Pentostatin

Name: Pentostatin
Brand: Tocris Bioscience
SKU: 2033

Tocris Bioscience, part of Bio-Techne | Catalog # 2033

Citations (32)

COA / SDS

Adenosine deaminase inhibitor

Key Product Details

Description:	Adenosine deaminase inhibitor
Alternative Names:	Deoxycoformycin
Chemical Name:	(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Purity:	≥98% (HPLC)
Molecular Weight:	268.27

View Full Technical Details for Pentostatin

Technical Data
Citations

Biological Activity for Pentostatin

Pentostatin is an irreversible inhibitor of adenosine deaminase (K_i = 2.5 pM). Anticancer agent.

Technical Data for Pentostatin

M. Wt	268.27
Formula	C₁₁H₁₆N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	53910-25-1
PubChem ID	439693
InChi Key	FPVKHBSQESCIEP-JQCXWYLXSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pentostatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.83	100
	DMSO	20.12	75

Preparing Stock Solutions for Pentostatin

The following data is based on the product molecular weight 268.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

Molarity Calculator

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Reconstitution Calculator

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References for Pentostatin

References are publications that support the biological activity of the product.

Nabhan Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res.
Klohs and Kraker Pentostatin: future directions. Pharmacol.Rev. 1992 PMID: 1480666

Product Documents for Pentostatin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Pentostatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov