PDZ1 Domain inhibitor peptide

Name: PDZ1 Domain inhibitor peptide
Brand: Tocris Bioscience
SKU: 2207

Tocris Bioscience, part of Bio-Techne | Catalog # 2207

COA / SDS

Disrupts interaction between GluK2 and PSD-95 PDZ1 domain

Discontinued Product

2207 has been discontinued. View all Kainate Receptor Peptides products.

Key Product Details

Description:	Disrupts interaction between GluK2 and PSD-95 PDZ1 domain
Molecular Weight:	819.95

View Full Technical Details for PDZ1 Domain inhibitor peptide

Technical Data
Citations

Biological Activity for PDZ1 Domain inhibitor peptide

PDZ1 Domain inhibitor peptide is a novel cyclic peptide that disrupts interaction between GluK2 (formerlyy GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for PDZ1 Domain inhibitor peptide

M. Wt	819.95
Formula	C₃₈H₆₁N₉O₁₁
Single Letter Sequence	YKKTEAV (Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))
Storage	Desiccate at -20°C
CAS Number	1315378-73-4
PubChem ID	90488746
InChi Key	XXRRADBJCXMGOW-RMLJCASOSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PDZ1 Domain inhibitor peptide

References are publications that support the biological activity of the product.

Piserchio Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 2004 PMID: 15123241

PDZ1 Domain inhibitor peptide

Tocris Bioscience, part of Bio-Techne | Catalog # 2207

Key Product Details

Biological Activity for PDZ1 Domain inhibitor peptide

Technical Data for PDZ1 Domain inhibitor peptide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PDZ1 Domain inhibitor peptide

Product Documents for PDZ1 Domain inhibitor peptide

COA

Certificate of Analysis

SDS

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