PD 334581

Name: PD 334581
Brand: Tocris Bioscience
SKU: 4824

Tocris Bioscience, part of Bio-Techne | Catalog # 4824

Citations (4)

COA / SDS

MEK1 inhibitor

Key Product Details

Description:	MEK1 inhibitor
Chemical Name:	N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine
Purity:	≥98% (HPLC)
Molecular Weight:	545.3

View Full Technical Details for PD 334581

Technical Data
Citations

Biological Activity for PD 334581

PD 334581 is an inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).

Compound Libraries for PD 334581

PD 334581 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 334581

M. Wt	545.3
Formula	C₂₀H₁₉F₃IN₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	548756-68-9
PubChem ID	5287529
InChi Key	LZZYEMSEMRUPIM-UHFFFAOYSA-N
Smiles	FC1=CC(I)=CC=C1NC2=C(F)C(F)=CC=C2C3=NN=C(NCCN4CCOCC4)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 334581

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	54.53	100
	ethanol	5.45	10

Preparing Stock Solutions for PD 334581

The following data is based on the product molecular weight 545.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.17 mL	18.34 mL
5 mM	0.37 mL	1.83 mL	3.67 mL
10 mM	0.18 mL	0.92 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for PD 334581

References are publications that support the biological activity of the product.

Ohren Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 2004 PMID: 15543157
Zhang Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 2009 PMID: 19104514