PD 158780

Tocris Bioscience, part of Bio-Techne | Catalog # 2615

Potent ErbB receptor family inhibitor
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Key Product Details

Description

Potent ErbB receptor family inhibitor

View all EGF Receptor Inhibitors »

Product Description

PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

Product Specifications

Molecular Weight

330.18

Formula

C14H12BrN5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine

CAS Number

171179-06-9

PubChem ID

4707

InChI Key

KFHMLBXBRCITHF-UHFFFAOYSA-N

SMILES

CNC1=NC=C2N=CN=C(NC3=CC=CC(Br)=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.01 100
Ethanol 8.25 25

Preparing Stock Solutions for PD 158780

The following data is based on the product molecular weight 330.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.29 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.30 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

Calculators

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Reconstitution Calculator

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Product Documents for PD 158780

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 158780

For research use only

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