PD 146176

Tocris Bioscience, part of Bio-Techne | Catalog # 2850

Selective 15-lipoxygenase inhibitor
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Key Product Details

Description

Selective 15-lipoxygenase inhibitor

View all Lipoxygenase Inhibitors »

Product Description

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

Product Specifications

Molecular Weight

237.32

Formula

C15H11NS

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

CAS Number

4079-26-9

PubChem ID

297589

InChI Key

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

SMILES

C12=CC=CC=C1C3=C(C(C=CC=C4)=C4SC3)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 100
Ethanol 11.87 50

Preparing Stock Solutions for PD 146176

The following data is based on the product molecular weight 237.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.14 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Calculators

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Reconstitution Calculator

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Product Documents for PD 146176

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 146176

For research use only

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