PD 123319 ditrifluoroacetate

Name: PD 123319 ditrifluoroacetate
Brand: Tocris Bioscience
SKU: 1361
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1361

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Citations (23)

COA / SDS

Potent and selective non-peptide AT2 antagonist

Key Product Details

Description:	Potent and selective non-peptide AT₂ antagonist
Chemical Name:	(6S)1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	736.67

View Full Technical Details for PD 123319 ditrifluoroacetate

Technical Data
Citations / Reviews (1)

Biological Activity for PD 123319 ditrifluoroacetate

PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT₂ receptor antagonist. IC₅₀ values are 34 and 210 nM in rat adrenal tissue and brain respectively.

Technical Data for PD 123319 ditrifluoroacetate

M. Wt	736.67
Formula	C₃₁H₃₂N₄O₃.2CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	136676-91-0
PubChem ID	6604951
InChi Key	GPKQIEZLHVGJQH-ZXVJYWQYSA-N
Smiles	O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)N1[C@H]([C@](O)=O)CC(N(CC3=CC(C)=C(N(C)C)C=C3)C=N2)=C2C1.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 123319 ditrifluoroacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	51.06	100

Preparing Stock Solutions for PD 123319 ditrifluoroacetate

The following data is based on the product molecular weight 736.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.36 mL	6.79 mL	13.57 mL
5 mM	0.27 mL	1.36 mL	2.71 mL
10 mM	0.14 mL	0.68 mL	1.36 mL
50 mM	0.03 mL	0.14 mL	0.27 mL

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References for PD 123319 ditrifluoroacetate

References are publications that support the biological activity of the product.

Boulay Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 1992 PMID: 1569928
Tamura Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 2000 PMID: 10994755
Blankley Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT₂ subtype. J.Med.Chem. 1991 PMID: 1956044