PB 28 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2562
High affinity σ2 agonist
Product Description
PB 28 dihydrochloride is a high affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.Product Specifications
Molecular Weight
443.50
Formula
C24H38N2O.2HCl
Storage
Desiccate at +4°C
Purity
≥99% (HPLC)
Chemical Name
1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
CAS Number
172907-03-8
PubChem ID
46861545
InChI Key
DSRBJOQIBXACIV-UHFFFAOYSA-N
SMILES
COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.87 | 20 with gentle warming |
Preparing Stock Solutions
for PB 28 dihydrochloride
The following data is based on the product molecular weight 443.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.27 mL | 56.37 mL | 112.74 mL |
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 2 mM | 1.13 mL | 5.64 mL | 11.27 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Colabufo A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder. Naunyn-Schmied.Arch.Pharmacol.
- Colabufo Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines. Naunyn-Schmied.Arch.Pharmacol.
- Berardi New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem. 1996 PMID: 8568804
Product Specific Notices for PB 28 dihydrochloride
For research use only
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