Paprotrain

Name: Paprotrain
Brand: Tocris Bioscience
SKU: 4813

Tocris Bioscience, part of Bio-Techne | Catalog # 4813

COA / SDS

Reversible inhibitor of MKLP-2

Discontinued Product

4813 has been discontinued. View all Kinesin Inhibitors products.

Key Product Details

Description:	Reversible inhibitor of MKLP-2
Chemical Name:	(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Purity:	≥99% (HPLC)
Molecular Weight:	245.28

View Full Technical Details for Paprotrain

Technical Data
Citations

Biological Activity for Paprotrain

Paprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (K_i = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC₅₀ = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

Technical Data for Paprotrain

M. Wt	245.28
Formula	C₁₆H₁₁N₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	57046-73-8
PubChem ID	12248889
InChi Key	YMYYQRZCCKBFBE-MDWZMJQESA-N
Smiles	N#C/C(C3=CNC2=CC=CC=C23)=C\C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Paprotrain

References are publications that support the biological activity of the product.

Tcherniuk Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 2010 PMID: 20857469

Paprotrain

Tocris Bioscience, part of Bio-Techne | Catalog # 4813

Key Product Details

Biological Activity for Paprotrain

Technical Data for Paprotrain

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Paprotrain

Product Documents for Paprotrain

COA

Certificate of Analysis

SDS

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