PAOPA

Name: PAOPA
Brand: Tocris Bioscience
SKU: 5041

Tocris Bioscience, part of Bio-Techne | Catalog # 5041

COA / SDS

Allosteric modulator of D2 receptors

Discontinued Product

5041 has been discontinued. View all Dopamine D2 Receptor Modulators products.

Key Product Details

Description:	Allosteric modulator of D₂ receptors
Chemical Name:	(3R)-2-Oxo-3-[[(2S)-2-Pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	254.29

View Full Technical Details for PAOPA

Technical Data
Citations

Biological Activity for PAOPA

PAOPA is an allosteric modulator of dopamine D₂ receptors. Prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized animal model of schizophrenia.

Technical Data for PAOPA

M. Wt	254.29
Formula	C₁₁H₁₈N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	114200-31-6
PubChem ID	44281634
InChi Key	QXHVGEXNEZRSGG-JGVFFNPUSA-N
Smiles	O=C1[C@H](N[C@]([C@H]2NCCC2)=O)CCN1CC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PAOPA

References are publications that support the biological activity of the product.

Tan Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective DA D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides 2011 PMID: 23416534
Dyck PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the DA D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophre Schizophr.Res. 2011 PMID: 21036015
Beyaert PAOPA, a potent DA D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. Eur.Neuropsychopharmacol. 2013 PMID: 22658400

PAOPA

Tocris Bioscience, part of Bio-Techne | Catalog # 5041

Key Product Details

Biological Activity for PAOPA

Technical Data for PAOPA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PAOPA

Product Documents for PAOPA

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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